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折扣/货期| 货号：GTX57200 | 规格：500μl | 目录价：￥9700 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TFE3 antibody [IHC672]
别名:
Transcription Factor Binding To Ighm Enhancer 3 , Rccp2 , Rccx1 , Tfea , Bhlhe33 , Tfe3
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P
同种型:
IgG1
免疫原:
Recombinant Human TFE3 protein.
克隆性:
Monoclonal
克隆号:
IHC672
纯化方式:
Protein A purified
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Tris, 1% BSA, 0.09% Sodium azide.
生产商:
GeneTex
功能与背景:
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion
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