Tie2/VEGFR2 Kinase-IN-2-抑制剂-深圳欣博盛生物科技有限公司

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Tie2/VEGFR2 Kinase-IN-2

品牌：Cayman

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说明书

折扣/货期

货号：42544-10 mg	规格：10 mg	目录价：￥4221
货号：42544-25 mg	规格：25 mg	目录价：￥8214
货号：42544-5 mg	规格：5 mg	目录价：￥2345
货号：42544-50 mg	规格：50 mg	目录价：￥14070

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Tie2/VEGFR2 Kinase-IN-2

别名:

Tie2/Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor 2|Tie2/Vascular Endothelial Growth Factor Receptor 2 Kinase-IN-2|Tie2/VEGFR2 Kinase Inhibitor 2|Tunica Interna Endothelial Cell Kinase 2/Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor 2|Tunica Interna Endothelial Cell Kinase 2/Vascular Endothelial Growth Factor Receptor 2 Kinase-IN-2|Tunica Interna Endothelial Cell Kinase 2/VEGFR2 Inhibitor 2|Tunica Interna Endothelial Cell Kinase 2/VEGFR2-IN-2

产品描述:

A Tie2 and VEGFR inhibitor (IC50s = 13.49 and 7.76 nM, respectively); selective for Tie2 and VEGFR2 over Akt3, Cdk2, EGFR, and GSK3 (IC50s = >10,000, >10,000, 10,000, and 2,187 nM, respectively) but does inhibit VEGFR1 and VEGFR3 (IC50s = 8.51 and 7.59 nM, respectively); inhibits VEGF-induced increases in the proliferation of HUVECs and GM-CSF-induced increases in Tie2 autophosphorylation in NIH3T3 fibroblasts expressing chimeric FMS and Tie2 receptors (IC50s = 2.6 and 18.3 nM, respectively); reduces tumor volume and intratumoral vessel density in an HT-29 colon cancer mouse xenograft model at 3, 10, or 30 mg/kg per day; prevents decreases in body temperature in a mouse model of Tnf-α-induced lethal shock at 20 mg/kg

保存温度:

-20

运输温度:

-20

预期分子量:

431.343332

产品形式:

A solid

纯度:

≥98%

CAS号:

501693-48-7