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折扣/货期| 货号：GTX83493 | 规格：100μl | 目录价：￥7300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TIF1 gamma antibody [6B7]
别名:
tripartite motif containing 33 , ECTO , PTC7 , RFG7 , TF1G , TIF1G , TIF1GAMMA , TIFGAMMA
反应种属:
Human
宿主来源:
Mouse
实验应用:
ICC/IF, IHC-P, WB
同种型:
IgG2b
免疫原:
Human recombinant protein fragment corresponding to amino acids 887-1046 of human Trim33 (NP_056990) produced in E.coli.
克隆性:
Monoclonal
克隆号:
6B7
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
0.85 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
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