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折扣/货期| 货号：V8755-100UG | 规格：100 ug | 目录价：￥6652.1 |
| 货号：V8755-20UG | 规格：20 ug | 目录价：￥3082.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TIM-3 Antibody / HAVCR2
产品描述:
TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cel tonsil, lymph node or spleen. ls (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
反应种属:
Human
宿主来源:
Mouse
实验应用:
WB, IHC-P
同种型:
Mouse IgG2b, kappa
免疫原:
A portion of amino acids 22-202 from the human protein was used as the immunogen for the TIM3 antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
TIM3/4025
纯化方式:
Protein G affinity chromatography
保存温度:
Store the TIM3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
产品形式:
Purified
存储溶液:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
产地:
美国
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