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折扣/货期| 货号：GTX27369 | 规格：50μg | 目录价：￥6500 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TNF Receptor II antibody [HM102]
别名:
CD120b,TBPII,TNF receptor superfamily member 1B,TNFBR,TNFR1B,TNFR2,TNFR75,TNFR80,TNFRII,TNFRSF1B,p75,p75TNFR,TNF receptor II
反应种属:
Mouse
宿主来源:
Rat
实验应用:
Activation, ELISA, FCM, IHC-Fr, IP, WB
靶标/特异性:
The monoclonal antibody HM102 recognizes the extracellular part of membrane-bound TNF-RII as well as the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist. The antibody is a agonistic receptor modulating antibody. It enhances in vitro TNF alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII.
同种型:
IgG2a
免疫原:
The monoclonal antibody HM102 recognizes the extracellular part of membrane-bound TNF Receptor II as well as the soluble form of TNF Receptor II which is generated by proteolytic cleavage of the extracellular domain.
克隆性:
Monoclonal
克隆号:
HM102
纯化方式:
Protein G purified
偶联:
Unconjugated
产品浓度:
100 μg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
运输温度:
4°C
预期分子量:
48
产品形式:
Liquid
存储溶液:
Filter-sterilized PBS, 0.1% BSA, no preservatives.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
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