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折扣/货期| 货号：AG-CR1-3625-M005 | 规格：5 mg | 目录价：￥720 |
| 货号：AG-CR1-3625-M025 | 规格：25 mg | 目录价：￥1800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Tofacitinib
别名:
CP-690550; Xeljanz; Tasocitinib
产品描述:
Potent cell permeable JAK3 inhibitor (IC50 = 1nM). Shows also JAK-1 inhibitory activity. Immunosuppressive and anti-inflammatory agent. Inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional selectivity over JAK2-paired receptors. Blocks downstream STAT signaling, resulting in potent inhibition of several cytokines, including interleukins 2, 4, 7, 9, 15 and 21, which are integral to lymphocyte activation, function and proliferation. Investigated for several autoimmune disorders including, rheumatoid arthritis and psoriasis. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19). PRK1 inhibitor.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
312.4
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98%
CAS号:
477600-75-2
分子式:
C16H20N6O
溶解度:
Soluble in DMSO or ethanol.
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