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折扣/货期| 货号：SIH-540-10MG | 规格：10 mg | 目录价：￥1152 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Tolcapone
别名:
(3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone, Tolcapone, Tasmar, Ro 40-7592
产品描述:
COMT inhibitor
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
273.2
产品形式:
Yellow powder
产地:
加拿大
功能与背景:
Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes1. Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity2. Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo3. Inhibits O-methylation of exogenous polyphenols such as EGCG4. Cell permeable.
纯度:
>98% (TLC); NMR (Conforms)
来源:
Synthetic
CAS号:
134308-13-7
分子式:
C14H11NO5
溶解度:
Soluble in DMSO (25 mg/ml), or ethanol (25 mg/ml)
PubChem CID:
4659569
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