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折扣/货期| 货号：GTX35137 | 规格：100μg | 目录价：￥7000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Topoisomerase II alpha antibody [TOP2A/1361]
别名:
TOP2 , TOP2A , TP2A , topoisomerase (DNA) II alpha , Topoisomerase II alpha , Topo II alpha , DNA topoisomerase II alpha
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
ICC/IF, IHC-P, Protein Array, WB
靶标/特异性:
KO/KD validation is based on published data (PMID: 34180392).
同种型:
IgG2b
免疫原:
Recombinant human Topoisomerase II alpha fragment (aa1352-1493)
克隆性:
Monoclonal
克隆号:
TOP2A/1361
纯化方式:
Protein A/G purified
偶联:
Unconjugated
产品浓度:
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
174
产品形式:
Liquid
存储溶液:
PBS, 0.05% BSA, 0.05% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
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