Topoisomerase II alpha (phospho Ser1106) antibody-多抗-深圳欣博盛生物科技有限公司

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Topoisomerase II alpha (phospho Ser1106) antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX55437

规格：100μl

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Topoisomerase II alpha (phospho Ser1106) antibody

别名:

DNA topoisomerase II alpha , TOP2 , TP2A

反应种属:

Human

宿主来源:

Rabbit

实验应用:

IHC-P, WB

同种型:

IgG

免疫原:

Peptide sequence around phosphorylation site of serine 1106 (E-E-S(p)-D-N) derived from human Topoisomerase II alpha.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

174

产品形式:

Liquid

存储溶液:

PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

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