TPH1 Antibody / Tryptophan Hydroxylase-单抗-深圳欣博盛生物科技有限公司

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TPH1 Antibody / Tryptophan Hydroxylase

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V4147SAF-100UG

规格：100 ug

目录价：￥6652.1

产品详情

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产品名称:

TPH1 Antibody / Tryptophan Hydroxylase

产品描述:

Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate, and is likely to be involved in the formation of the hydroxylating intermediate. TPH is both the first and rate-limiting-step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, LDOPA, which is used as a common therapy for Parkinson s disease (PD) patients, inhibits TPH function which, subsequently, is thought to contribute to the onset of depression in PD patients.

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P

同种型:

Mouse IgG2, kappa

免疫原:

Recombinant full-length human TPH1 protein was used as the immunogen for the TPH1 antibody.

克隆性:

Monoclonal (mouse origin)