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折扣/货期| 货号：GTX70255 | 规格：100μl | 目录价：￥4300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TSG101 antibody [4A10]
别名:
tumor susceptibility 101 , TSG10 , VPS23
产品描述:
TSG101 antibody [4A10] is a well-validated and highly cited mouse monoclonal antibody that detects TSG101, a protein of 390 amino acids and a predicted molecular weight of 44 kDa that is a core constituent of the ESCRT-I complex. Reports have described it having both tumor suppressor and tumor enhancer activities. TSG101 is involved in exosome secretion and is commonly used as an exosome marker.
反应种属:
Dog, Hamster, Human, Monkey, Mouse, Pig, Rat, Zebrafish
宿主来源:
Mouse
实验应用:
ELISA, EM, FCM, ICC/IF, IHC, IHC (Free Floating), IHC-P, IP, WB
靶标/特异性:
Knockdown/Knockout validation was supported by references (PMID:27226592)
同种型:
IgG1
免疫原:
Amino acids 167-374 of TSG101 protein expressed in E. coli.
克隆性:
Monoclonal
克隆号:
4A10
纯化方式:
Purified by antigen-affinity chromatography.
偶联:
Unconjugated
产品浓度:
1.8 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
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