VEGFA antibody [HL1755]-单抗-深圳欣博盛生物科技有限公司

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VEGFA antibody [HL1755]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX637405	规格：100μl	目录价：￥4000
货号：GTX637405-S	规格：25μl	目录价：￥1700

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

VEGFA antibody [HL1755]

别名:

vascular endothelial growth factor A , MVCD1 , VEGF , VPF

反应种属:

Cat, Dog, Human, Mouse

宿主来源:

Rabbit

实验应用:

ICC/IF, WB

靶标/特异性:

This antibody is specific for human VEGFA protein, and it does not cross react with human VEGFB protein.

同种型:

IgG

免疫原:

Recombinant fragment of human VEGFA.

克隆性:

Monoclonal

克隆号:

HL1755

纯化方式:

Affinity purified by Protein A.

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, no preservatives.

生产商:

GeneTex

功能与背景:

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]

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