Vitamin D Receptor antibody-多抗-深圳欣博盛生物科技有限公司

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Vitamin D Receptor antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX79289

规格：100μl

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Vitamin D Receptor antibody

别名:

vitamin D (1,25-dihydroxyvitamin D3) receptor , Nr1i1

反应种属:

Avian, Chicken, Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

Gel supershift assays, IHC, IP, WB

同种型:

IgG

免疫原:

Synthetic Peptide: E(395) E H S K Q Y R C L S F Q P E C S M K(413)

克隆性:

Polyclonal

克隆号:

纯化方式:

Unpurified

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

Serum, 0.05% Sodium azide.

生产商:

GeneTex

功能与背景:

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expresion, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NRI1I.

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