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折扣/货期| 货号：GTX31604 | 规格：100μg | 目录价：￥6200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Wip1 antibody
别名:
protein phosphatase, Mg2+/Mn2+ dependent 1D , IDDGIP , PP2C-DELTA , WIP1
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
ELISA, IHC-P, WB
靶标/特异性:
At least two isoforms are known to exist; this antibody will only detect the larger isoform.
同种型:
IgG
免疫原:
Wip1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human Wip1.The immunogen is located within the last 50 amino acids of Wip1.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
67
产品形式:
Liquid
存储溶液:
PBS, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
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