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WISP1 antibody [7H14]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX53058

规格：100μg

目录价：￥8000

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

WISP1 antibody [7H14]

别名:

CCN4 , WISP1 , WISP1c , WISP1i , WISP1tc , WNT1 inducible signaling pathway protein 1 , cellular communication network factor 4

反应种属:

Human

宿主来源:

Mouse

实验应用:

同种型:

IgG2

免疫原:

Human recombinant WISP-1

克隆性:

Monoclonal

克隆号:

7H14

纯化方式:

Protein G purified

偶联:

Unconjugated

产品浓度:

500 μg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, no preservatives.

生产商:

GeneTex

功能与背景:

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

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