XBP1 antibody [1C4]-单抗-深圳欣博盛生物科技有限公司

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XBP1 antibody [1C4]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX83279

规格：100μl

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

XBP1 antibody [1C4]

别名:

X-box binding protein 1 , TREB-5 , TREB5 , XBP-1 , XBP2

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA, WB

同种型:

IgG1

免疫原:

Purified recombinant fragment of human XBP1(AA : 1-160) expressed in E. Coli.

克隆性:

Monoclonal

克隆号:

1C4

纯化方式:

Unpurified

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

Ascites, 0.03% Sodium azide.

生产商:

GeneTex

功能与背景:

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shu

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