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折扣/货期| 货号：GTX18371 | 规格：100μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ZAP70 antibody [1E7.2]
别名:
zeta chain of T cell receptor associated protein kinase 70 , ADMIO2 , IMD48 , SRK , STCD , STD , TZK , ZAP-70
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
ELISA, FCM, ICC/IF, IP, WB
同种型:
IgG1
免疫原:
The immunogen sequence is conjugated to KLH. peptide corresponding to amino acids 282-307 of human ZAP-70.
克隆性:
Monoclonal
克隆号:
1E7.2
纯化方式:
Purified immunoglobulin
偶联:
Unconjugated
产品浓度:
~1.5 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
70
产品形式:
Liquid
存储溶液:
PBS, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
ZAP70, a 70 kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling. Phosphorylation of tyrosines 315 and 319 plays an important role in mediating the positive and negative selection of T cells in thymus.Mutations in ZAP70 gene results in a form of Severe Combined Immunodeficiency Syndrome (SCID) in humans. ZAP70 expression also defines a subset of Chronic Lymphocytic Leukemia (CLL) in patients with unmutated Ig gene and poor clinical course. Recent studies suggest that protein levels of ZAP70 are elevated in B cells of CLL patients with non mutant heavy chain variable region (IgVH) but not those with the mutant regions. Recent evidence suggests that ZAP70 could be an excellent prognostic biomarker with high levels of the proteins indicating a poor prognosis.
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