4-1BB Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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4-1BB Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：96-966

规格：0.1 mg

目录价：￥8687.25

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

4-1BB Recombinant Protein

别名:

4-1BB

实验应用:

ELISA,WB

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

Tris with Glycine, Arginine and NaCl, pH7.5

产地:

美国

生产商:

Prosci

功能与背景:

4-1BB is also known as CD137, tumor necrosis factor receptor superfamily member 9 (TNFRSF9), induced by lymphocyte activation (ILA), is a co-stimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice. CD137 can enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, 4-1BB/4-1BBL co-stimulatory pathway has been shown to augment secondary CTL responses to several viruses, and meanwhile augment anti-tumor immunity. 4-1BB thus is a promising candidate for immunotherapy of human cancer. CD137 has been shown to interact with TRAF2.

纯度:

>92% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.

生物活性:

Measured by its binding ability in a functional ELISA. Immobilized Mouse B7-1, Fc Tag at 2 ug/mL (100 ul/well),can bind Mouse CTLA-4, His Tag with a linear range of 0.02-0.8 ng/mL.

Accession #:

NP_001070976

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