4-Hydroxytamoxifen-其他小分子化合物-深圳欣博盛生物科技有限公司

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4-Hydroxytamoxifen

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-H0150-M050	规格：50 mg	目录价：￥2100
货号：CDX-H0150-M250	规格：250 mg	目录价：￥7182

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

4-Hydroxytamoxifen

别名:

Afimoxifene; 4-OHT; cis/trans-4-Hydroxytamoxifen; (E/Z)-4-Hydroxytamoxifen; HTMX; 4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol

产品描述:

4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen, a selective estrogen receptor modulator (SERM) that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen acts as a tissue-selective agonist-antagonist of the estrogen receptors ERalpha and ERbeta. 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gamma. 4-Hydroxytamoxifen exhibits anticancer chemotherapeutic activity, inducing autophagy and vacuole formation as well as KRAS degradation in various cancer cell lines. In cardiac myocytes, 4-hydroxytamoxifen decreases Ca2+ amplitude, slowing relaxation and decreasing contractility. 4-Hydroxytamoxifen has also shown to be a potent inhibitor of the mitochondrial permeability transition (MPT).

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

387.51

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)