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折扣/货期| 货号：CDX-H0150-M050 | 规格：50 mg | 目录价：￥2100 |
| 货号：CDX-H0150-M250 | 规格：250 mg | 目录价：￥7182 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
4-Hydroxytamoxifen
别名:
Afimoxifene; 4-OHT; cis/trans-4-Hydroxytamoxifen; (E/Z)-4-Hydroxytamoxifen; HTMX; 4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
产品描述:
4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen, a selective estrogen receptor modulator (SERM) that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen acts as a tissue-selective agonist-antagonist of the estrogen receptors ERalpha and ERbeta. 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gamma. 4-Hydroxytamoxifen exhibits anticancer chemotherapeutic activity, inducing autophagy and vacuole formation as well as KRAS degradation in various cancer cell lines. In cardiac myocytes, 4-hydroxytamoxifen decreases Ca2+ amplitude, slowing relaxation and decreasing contractility. 4-Hydroxytamoxifen has also shown to be a potent inhibitor of the mitochondrial permeability transition (MPT).
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
387.51
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
68392-35-8
分子式:
C26H29NO2
促销活动
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