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折扣/货期| 货号：10-167 | 规格：0.1 mg | 目录价：￥9038.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Abciximab (ITGA2B_ITGB3) - Research Grade Biosimilar
别名:
c7E3
同种型:
Fab-G1-kappa
克隆性:
Recombinant Monoclonal
纯化方式:
>95%
偶联:
Unconjugated
产品浓度:
batch dependent
表达系统:
CHO cells
保存温度:
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚C for 1-2 weeks. Store at -20 ˚C for 12 months. Store at -80 ˚C for long term storage.
运输温度:
Blue Ice
存储溶液:
PBS buffer pH7.5
产地:
美国
生产商:
Prosci
功能与背景:
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3.Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen,von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.Abciximab binds to the intact platelet GPIIb/IIIa receptor,which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation.This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GPIIb/IIIa.By binding to the vitronectin receptor (also known as the αvβ3 integrin), abciximab blocks effects mediated by this integrin which include cell adhesion.Furthermore, abciximab blocks Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion.
上一个:cT84.66 (CEACAM5/CD66e) - Research Grade Biosimilar
下一个:Alg-991 (Urushiol) - Research Grade Biosimilar
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