官网链接
折扣/货期| 货号：SPR-107A | 规格：50 µg | 目录价：￥2003.4 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Active Human Recombinant GRP78 (Bip) Protein
别名:
BIP Protein, Grp78 Protein, HSPA5 Protein, MIF2 Protein, immunoglobulin heavy chain binding Protein
产品描述:
Active Human Recombinant GRP78 (Bip) Protein
反应种属:
Human
实验应用:
WB | SDS-PAGE | ATPase Activity Assay | Functional Assay | ELISA
纯化方式:
Affinity Purified
偶联:
His tag
产品浓度:
Lot/batch specific. See included datasheet.
表达系统:
E. coli
保存温度:
-20ºC
运输温度:
Blue Ice or 4ºC
预期分子量:
~78 kDa
存储溶液:
50mM Tris/HCl, pH 7.5, 150mM NaCl, 10% glycerol
产地:
加拿大
功能与背景:
GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3). In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia (Barnes), to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer's patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).
纯度:
>90%
生物活性:
ATPase active
Accession #:
NM_005347
您可能感兴趣的产品
Histone H3 (human, recombinant; PAD2 citrullinated)
货号：44508
Human Tau441 (2N4R) protein, mutant P301S (monomer)
货号：GTX17672-pro
Human Tau (K18) protein, mutant P301L (Pre-formed Fibrils)
货号：GTX17675-pro-S
Human alpha Synuclein protein (active, Pre-Formed Fibrils)
货号：GTX17669-pro-S
Human alpha Synuclein protein (Pre-Formed Fibrils)
货号：GTX17667-pro
Recombinant human activin E
货号：RP019-100MCG
Recombinant human BMP-4 protein
货号：RP011-100MCG
Recombinant human noggin protein
货号：RP009-100MCG
促销活动
精品推荐
相关产品推荐
Human Recombinant Alpha Synuclein (1-114) Monomers (C-terminal Truncated)
货号：SPR-536B
Human Recombinant Alpha Synuclein (1-114) Monomers (C-terminal Truncated)
货号：SPR-536C
Human Recombinant Alpha Synuclein (1-114) Monomers (C-terminal Truncated)
货号：SPR-536E
Human Recombinant Alpha Synuclein (1-114) PFFs (C-terminal Truncated)
货号：SPR-537B
Human Recombinant Alpha Synuclein (1-114) PFFs (C-terminal Truncated)
货号：SPR-537C
Human Recombinant Alpha Synuclein (1-114) PFFs (C-terminal Truncated)
货号：SPR-537E
复制QQ号成功，请打开QQ后添加好友进行咨询