官网链接
折扣/货期| 货号：SYN-1100-M001 | 规格：1 mg | 目录价：￥1204 |
| 货号：SYN-1100-M005 | 规格：5 mg | 目录价：￥1820 |
| 货号：SYN-1100-M010 | 规格：10 mg | 目录价：￥3024 |
| 货号：SYN-1100-M050 | 规格：50 mg | 目录价：￥8316 |
| 货号：SYN-1100-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Afatinib
别名:
Tovok; BIBW-2992
产品描述:
Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
486
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
439081-18-2
分子式:
C24H25ClFN5O3
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