Aftin-5

品牌：Adipogen

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说明书

折扣/货期

货号：AG-MR-C0015-M001	规格：1 mg	目录价：￥780
货号：AG-MR-C0015-M005	规格：5 mg	目录价：￥2760
货号：AG-MR-C0015-M025	规格：25 mg	目录价：￥9360

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Aftin-5

别名:

(2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol; Amyloidbeta Forty-Two Inducer 5

产品描述:

Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds).

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

354.5

产品形式:

solid

产地:

瑞士

纯度:

>98% (NMR)