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折扣/货期| 货号：11-240 | 规格：0.2 mg | 目录价：￥6405.75 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Alpha-Synuclein Recombinant Protein
别名:
SNCA,NACP,PARK1,alpha-Synuclein
实验应用:
WB
表达系统:
E. coli
保存温度:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
100 mM NaAC, pH7.0
产地:
美国
生产商:
Prosci
功能与背景:
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
纯度:
>90% as determined by SDS-PAGE.
Accession #:
NP_000336.1
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