官网链接
折扣/货期| 货号：GTX48719 | 规格：50μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ASPP1 antibody
别名:
protein phosphatase 1 regulatory subunit 13B , ASPP1 , p53BP2-like , p85
反应种属:
Human
宿主来源:
Rabbit
实验应用:
ELISA, WB
同种型:
IgG
免疫原:
Synthetic peptide corresponding to an internal sequence of human ASPP1.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography.
偶联:
Unconjugated
产品浓度:
0.33 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
120
产品形式:
Liquid
存储溶液:
20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.
生产商:
GeneTex
功能与背景:
ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, iASPP functionally inactivates p53. ASPPs may also regulate p63- and p73-mediated apoptosis. Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3. Not all cell cycle arrest genes are affected, such as p21. Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
您可能感兴趣的产品
Tafazzin Polyclonal Antibody
货号：44967
HFE antibody
货号：GTX135988-S
DC-SIGN antibody
货号：GTX135602-S
SARS-CoV-2 (COVID-19) nsp3 antibody
货号：GTX135589-S
SARS-CoV-2 (COVID-19) nsp12 antibody
货号：GTX135467-S
SARS-CoV-2 (COVID-19) Nucleocapsid antibody
货号：GTX135357-S
CD81 antibody
货号：GTX135297-S
GCN2 antibody
货号：GTX135252-S
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询