b-AP15-其他小分子化合物-深圳欣博盛生物科技有限公司

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b-AP15

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3552-M001	规格：1 mg	目录价：￥480
货号：AG-CR1-3552-M005	规格：5 mg	目录价：￥960

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

b-AP15

别名:

NSC 687852; 3E,5E-bis[(4-Nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-4-piperidinone

产品描述:

b-AP15 is a specific deubiquitinase (DUB) inhibitor. It inhibits ubiquitin-specific-processing protease 14 (USP14) and ubiquitin c-terminal hydrolase isozyme L5 (UCHL5; UCH37), two 19S regulatory particle proteasome-associated DUBs. It exhibits minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP and BAP1. Has been described to inhibit also the 20S proteasome with an IC50 comparable to that required for inhibiting the 19S regulatory particles. b-AP15 has anticancer properties and blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia. b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells. It induces apoptosis, ER stress and autophagy in several cancer cells. b-AP15 has anti-inflammatory properties inhibiting ERK1/2 and JNK phosphorylation, increasing IkappaBalpha levels and inhibiting NF-kappaB p65. b-AP15 inhibits the LPS/ATP-induced deubiquitination of NLRP3 and further increases NLRP3 ubiquitination. This leads to inhibition of NLRP3 activation, indicating that deubiquitination of NLRP3 by the priming and activation signals is critical for its activation.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

419.4

产品形式:

solid

产地:

瑞士

纯度:

>98%