BACE1 Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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BACE1 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：96-052

规格：0.2 mg

目录价：￥7581.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

BACE1 Recombinant Protein

别名:

BACE1, ASP2, BACE, FLJ90568, HSPC104, KIAA1149, Memapsin-2

实验应用:

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

50 mM tris, 100 mM glycine, pH7.5

产地:

美国

生产商:

Prosci

功能与背景:

Beta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), β-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. BACE1 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the APP. Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD.

纯度:

>85% as determined by SDS-PAGE.

生物活性:

Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK (Dpn) RR-NH2. The specific activity is > 1. 5 pmoles /min /μg.

Accession #:

NP_036236.1

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