BMP1 antibody-多抗-深圳欣博盛生物科技有限公司

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BMP1 antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX10855

规格：25μg

目录价：￥6600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

BMP1 antibody

别名:

bone morphogenetic protein 1 , OI13 , PCOLC , PCP , PCP2 , TLD

反应种属:

Human

宿主来源:

Rabbit

实验应用:

靶标/特异性:

Reacts with the C-terminal end of the long form of BMP-1 called mTld (mammalian Tolloid), the 987 amino acid form.

同种型:

IgG

免疫原:

synthetic peptide corresponding to the C-terminal end of the long form of human BMP-1

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

~1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

111

产品形式:

Liquid

存储溶液:

PBS, 50% Glycerol, 0.01% Sodium azide.

生产商:

GeneTex

功能与背景:

Bone morphogenetic protein 1 (BMP1) was first identified in osteogenic extracts of bone. It is an extracellular zinc endopeptidase, implicated in morphogenetic processes in a broad range of species. BMP1 is a member of the astacin family of metalloproteinases. The astacin family includes BMP1, astacin, meprin A and B, tolloid-like proteins, and choriolysin. BMP1 is involved in extracellular matrix (ECM) formation, suggesting that a functional link may exist between astacin metalloproteinases, growth factors, and cell differentiation and pattern formation during development. The name PCP reflects this enzymeis involvement in the collagen deposition of growing bone. The enzymes known as the procollagen C and N proteinases (PCP and PNP) are involved in the processing of fibrillar procollagen precursors to mature collagens, which is an essential requirement for fibril formation. PCP cleaves the C-terminus from procollagen, to allow the formation of mature, triplehelical collagen. The N-terminus is cleaved by the procollagen N-proteinase (PNP or ADAM-TS2). Defects in PNP have been linked to the skin disorder dermatosparaxis, and defects in BMP1 are thought to lead to aberrant collagen processing, and connective tissue disorders. Many forms of BMP1 have been reported, with varying truncation at the C-terminus. The long form of BMP1 is most similar to the tolloid-like proteins, which have extra EGF-like and CUB domains.

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