GM-CSF antibody-多抗-深圳欣博盛生物科技有限公司

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GM-CSF antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX10669

规格：25μg

目录价：￥5000

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GM-CSF antibody

别名:

colony stimulating factor 2 , Gm-csf , Gmcsf

反应种属:

Rat

宿主来源:

Goat

实验应用:

ELISA, WB

靶标/特异性:

By immunoblotting and ELISA, the antibody shows 30% cross-reactivity with recombinant mouse GM-CSF and 10% cross-reactivity with recombinant human GM-CSF.

同种型:

IgG

免疫原:

Purified recombinant rat GM-CSF expressed in E. coli.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, no preservatives.

生产商:

GeneTex

功能与背景:

Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells are well characterized: granulocyte-macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and interleukin-3 (IL-3, Multi CSF) Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating the final mitotic divisions and the terminal cellular maturation of partially differentiated hematopoietic progenitors.GMCSF induces myeloid progenitor cells from bone marrow to form colonies containing macrophages and granulocytes in a semisolid media. It acts upon mature macrophages, eosinophils and neutrophils to stimulate various functional activities. GMCSF is an acidic glyocprotein (18-22 kDa in human and 23 kDa inmouse) which binds to high affinity receptors on GMCSF sensitive cells. Although human and mouse GMCSF share 54% amino acid sequence homology, their biological actions are species-specific. The actions of GMCSF and the binding of GMCSF to its receptor are modulated by other growth factors and additional forms of CSF. Human GMCSF is presently undergoing clinical trials for therapy of several diseases and syndromes.

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