Bufalin-其他小分子化合物-深圳欣博盛生物科技有限公司

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Bufalin

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-0533-M010	规格：10 mg	目录价：￥720
货号：AG-CN2-0533-M050	规格：50 mg	目录价：￥2880

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Bufalin

别名:

(3beta,5beta)-3,14-Dihydroxy-bufa-20,22-dienolide; NSC 89595; BRN 5141601

产品描述:

Bufalin is a cardiotonic steroid with anaesthetic, blood pressure stimulatory and respiratory activities. It is a potent Na+/K+-ATPase transporter inhibitor (Kd = 42, 45, and 40nM for the alpha1, alpha2, and alpha3 subunits, respectively). Bufalin has anticancer effects in a variety of cancer cell lines both in vitro and in vivo. It inhibits cancer cell proliferation, induces cell cycle arrest, induces apoptosis and autophagy, inhibits angiogenesis and neovascularization, induces cell differentiation, inhibits cancer metastasis and invasion, and enhances chemotherapeutic drug sensitivity through multiple kinase targets and also the Na+/K+-ATPase transporter. It also inhibits proteins of the steroid receptor coactivator family, such as SRC-1 and SRC-3 at 5nM. Bufalin has anti-inflammatory effects by modulating nuclear factor-kappaB (NF-kappaB) signaling and down-regulating inflammatory-related genes such as cyclooxygenases, lipoxygenases, inducible nitric oxide synthase (iNOS), and thereby decrease nitric oxide and prostaglandin E2 (PGE2) production.

宿主来源:

Isolated from venenum bufonis.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

386.5

产品形式:

solid

产地:

瑞士