CA77.1 [CMA Activator]-其他小分子化合物-深圳欣博盛生物科技有限公司

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CA77.1 [CMA Activator]

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-0165-M005	规格：5 mg	目录价：￥840
货号：AG-CR1-0165-M025	规格：25 mg	目录价：￥3360

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

CA77.1 [CMA Activator]

别名:

N-[4-(6-Chloroquinoxalin-2-yl)phenyl]acetamide

产品描述:

CA77.1 is a novel selective chaperone-mediated autophagy (CMA) activator by increasing the expression of the lysosomal receptor for this pathway, LAMP2A, in lysosomes. Chaperone-mediated autophagy (CMA), is a selective autophagy shown to degrade neurodegeneration-related proteins such as alpha-synuclein (alpha-syn) or tau. Loss of neuronal CMA leads to altered neuronal function, selective changes in the neuronal metastable proteome and proteotoxicity. Chemical upregulation of CMA has been shown to ameliorate pathology in AD experimental mouse models, reduce brain pathology and improve disease phenotype. CA77.1 is able to activate CMA in vitro and in vivo (in contrary to it's derivative AR7 which was not suitable for in vivo application). CA77.1 is able to activate CMA in vivo, and demonstrates brain penetrance and favorable pharmacokinetics. It has been shown in animal studies that administration of CA77.1 to enhance chaperone-mediated autophagy, may help to degrade toxic pathogenic protein products such as tau proteins and has potential applications in the treatment of Alzheimer's disease.

宿主来源:

Synthetic

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

297.7

产品形式:

solid

产地:

瑞士