Cabozantinib-其他小分子化合物-深圳欣博盛生物科技有限公司

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Cabozantinib

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-C0755-M010	规格：10 mg	目录价：￥2030
货号：CDX-C0755-M050	规格：50 mg	目录价：￥6440

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Cabozantinib

别名:

BMS-907351; XL184

产品描述:

Cabozantinib is a potent multi-targeted receptor tyrosine kinase (RTK) inhibitor of endothelial growth factor receptor 2 (VEGFR2) (IC50=0.035nM), the hepatocyte growth factor receptor c-Met (IC50=1.3nM), AXL (IC50=7nM), fms like tyrosine kinase 3 (FLT3) (IC50=11.3nM), mast/stem cell growth factor (KIT) (IC50=4.6nM), RET (IC50=5.2nM), tyrosine-protein kinase receptor (TIE-2) (IC50=14.3nM) and RON (IC50=124nM). Cabozantinib reduces cell proliferation and vascular density. It also induces apoptosis and intratumoral hypoxia. Cabozantinib exhibits dose-related tumor growth inhibition, tumor regression, angiogenesis and/or metastasis inhibition in a broad range of preclinical tumor models. The anticancer compound cabozantinib has undergone clinical trial in a broad number of cancers, including thyroid carcinoma, prostate cancer, ovarian cancer, melanoma, breast cancer, non-small cell lung cancer, hepatocellular cancer, renal cell carcinoma and glioblastoma.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

501.5

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)