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折扣/货期| 货号：11-323 | 规格：0.1 mg | 目录价：￥10126.35 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Canine TIGIT Recombinant Protein
别名:
TIGIT,VSIG9,VSTM3
实验应用:
ELISA,WB
表达系统:
HEK293 cells
保存温度:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
PBS, pH7.4
产地:
美国
生产商:
Prosci
功能与背景:
TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity. TIGIT expressing CD8+ T cells has been shown to be expanded and associated with clinical markers of HIV disease progression in a diverse group of HIV infected individuals. TIGIT and PD-1 has been shown to be over expressed on tumor antigen-sepcific (TA-specific) CD8+ T cells and CD8+ tumor infiltrating lymphocytes (TILs) from individuals with melanoma. Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of TA-specific CD8+ T cells and TIL CD8+ T cells.
纯度:
>90% as determined by SDS-PAGE.
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