官网链接
折扣/货期| 货号：96-472 | 规格：0.05 mg | 目录价：￥8687.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CD124 Recombinant Protein
别名:
IL4R, CD124, IL4RA
实验应用:
WB
表达系统:
HEK293 cells
保存温度:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
PBS, pH7.4
产地:
美国
生产商:
Prosci
功能与背景:
IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132).
Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL13Ra1 to form the type II receptor which is responsive to both IL4 and IL13. Interleukin-4 receptor has been shown to interact with SHC1.
纯度:
>95% as determined by SDS-PAGE.
生物活性:
Measured by its ability to inhibit IL4dependent proliferation of TF-1 human erythroleukemic cells. Approximately 253 ng/mL of rhIL4R will inhibit 50% of the biological response due to 0. 2 ng/mL of rhIL-4.
Accession #:
NP_000409.1
您可能感兴趣的产品
Influenza B Strain B/Hong Kong 5/72 Antigen
货号：11-576
TMIGD2 Recombinant Protein
货号：RF16120-01
TIM3 Recombinant Protein
货号：RF16100-01
B7-H3 Recombinant Protein
货号：RF16090-01
LAG-3 Recombinant Protein
货号：RF16080-01
B7-H5 Recombinant Protein
货号：RF16070-01
LIGHT Recombinant Protein
货号：RF16060-01
B7-1 Recombinant Protein
货号：RF16040-01
促销活动
复制QQ号成功，请打开QQ后添加好友进行咨询