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折扣/货期| 货号：81-206 | 规格：100 ul | 目录价：￥9477 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CD13/ANPEP Rabbit Recombinant Antibody
别名:
APN; AP-M; AP-N; CD13; LAP1; P150; PEPN; hAPN; GP150; CD13/ANPEP
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
WB, IF-P, IHC-P, ELISA
同种型:
IgG
克隆性:
Monoclonal
纯化方式:
Affinity purification
偶联:
Unconjugated
产品浓度:
Batch dependent
保存温度:
Store at -20℃. Avoid freeze / thaw cycles.
运输温度:
Blue Ice
预期分子量:
160kDa
产品形式:
Liquid
存储溶液:
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
产地:
美国
生产商:
Prosci
功能与背景:
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma.
Accession #:
P15144
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