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折扣/货期| 货号：90-289 | 规格：10 ug | 目录价：￥8687.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CD40L multimeric Recombinant Protein
别名:
ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFSF5, ADIPOQ-CD40L
产品浓度:
0.1mg/ml after reconstitution.
表达系统:
CHO cells
保存温度:
Stable for at least 6 months after receipt when stored at -20˚C.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
Contains PBS. Reconstitute with 100 μl sterile water.
产地:
美国
生产商:
Prosci
功能与背景:
MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L™ has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
纯度:
>95% (SDS-PAGE).
Endotoxin level is less than 0.02EU/ μg purified protein (LAL test; Lonza).
Endotoxin level is less than 0.02EU/ μg purified protein (LAL test; Lonza).
生物活性:
Induces B cell activation (as demonstrated by dose-dependent upregulation of CD86).
Accession #:
Q9Z2V2
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