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折扣/货期| 货号：96-045 | 规格：0.1 mg | 目录价：￥8687.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
CD80 Recombinant Protein
别名:
CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
实验应用:
WB
表达系统:
HEK293 cells
保存温度:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
50 mM tris, 100 mM glycine, pH7.5
产地:
美国
生产商:
Prosci
功能与背景:
B71 and B72, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response.
B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
纯度:
>95% as determined by SEC-HPLC and SDS-PAGE.
生物活性:
Measured by its binding ability in a functional ELISA. Immobilized Human B7-1, Fc Tag (HPLC-verified) at 2 ug/mL (100 ul/well) can bind Biotinylated Human CTLA-4 with a linear range of 50 - 500 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized Human B7-1, Fc Tag (HPLC-verified) at 2 ug/mL (100 ul/well) can bind Human CTLA-4, Strep Tag with a linear range of 1-20 ng/mL.
Accession #:
NP_005182.1
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