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折扣/货期| 货号：GTX11062 | 规格：50μl | 目录价：￥5000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Cofilin antibody
反应种属:
Dog, Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
ICC/IF, IHC, WB
靶标/特异性:
Reacts with muscle and non-muscle cofilin.
同种型:
IgG
免疫原:
synthetic peptide corresponding to human cofilin sequence, (amino acids 154-166) with N-terminal cysteine added, conjugated to KLH. The corresponding sequence is identical in pig and rat non-muscle cofilin and differs by three amino acids from that of human and chicken muscle cofilin.
克隆性:
Polyclonal
克隆号:
纯化方式:
IgG fraction
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
Cofilin is a small phosphoinositide-sensitive, actin-binding protein capable of depolymerizing actinfilaments in vitro. Under certain conditions, it fragments the filaments and accelerates actin subunit dissociation from their epointedi (minus) ends. Cofilin binds stoichiometrically to monomeric G-actin and to actin protomers in filaments in an apparent pH-dependent, Ca2+- independent manner. Actin-ADP is preferentially bound. Cofilin intercalates between longitudinally associated actin monomers within the filament and distorts its helical twist. Cofilin is very similar to destrin/ ADF (Actin Depolymerizing Factor), a related gelsolinlike actin filament-severing protein. Mammalian cofilin has non-muscle (NM-CF, CF-L1) and muscle (M-CF, CF-L2) isoforms. Cofilin is ubiquitous in tissues of eukaryotes and is especially abundant in neuronal tissues. It can shuttle between the cytoplasm and the nucleus in response to various stresses or signals, and may translocate from the cytoplasm to the plasma membrane in various cells. Cofilin is present together with destrin in eHirano bodiesi in certain brain neurons of dementia patients. Cofilin is essential for viability and is important for many cellular processes involving actin remodeling such as motility at the leading edge of cells, polarized cell growth, endocytosis, phagocytosis, cellular activation, cytokinesis, and pathogen intracellular motility. In vivo activity of vertebrate cofilin is regulated through reversible phosphorylation and dephosphorylation at the serine 3 residue. The phosphorylated form is inactive and incapable of association with actin. Phosphorylation of cofilin is regulated in vertebrates by at least four protein kinases: LIM Kinase 1, LIM Kinase 2, Testicular Kinase 1, and Testicular Kinase 2, whereas its dephosphorylation in co-stimulated human lymphocytes is carried out by serine phosphatases PP1 and PP2A.
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