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折扣/货期| 货号：CDX-C0706-M010 | 规格：10 mg | 目录价：￥1498 |
| 货号：CDX-C0706-M050 | 规格：50 mg | 目录价：￥6482 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Combretastatin A4
别名:
1-(3,4,5-Trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl) ethane 3,4,5-trimethoxy-3'-hydroxy-4'-methoxystilbene; CA4; CRC 87-09; NSC 817373
产品描述:
Combretastatin A4 is a natural stilbenoid phenol originally isolated from an African shrub, Combretum caffrum. It is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. CA4 was shown to impede tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma) and MCF-7 (breast cancer). It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A-4 is the active component of combretastatin A-4 phosphate, a prodrug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. Combretastatin A-4 is therefore a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis.
宿主来源:
Plant
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
316.35
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
117048-59-6
分子式:
C18H20O5
溶解度:
Soluble in DMSO (10mg/ml), ethanol (5mg/ml) or DMF (10mg/ml). Insoluble in water.
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