Combretastatin A4-其他小分子化合物-深圳欣博盛生物科技有限公司

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Combretastatin A4

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-C0706-M010	规格：10 mg	目录价：￥1498
货号：CDX-C0706-M050	规格：50 mg	目录价：￥6482

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Combretastatin A4

别名:

1-(3,4,5-Trimethoxyphenyl)-2-(3'-hydroxy-4'-methoxyphenyl) ethane 3,4,5-trimethoxy-3'-hydroxy-4'-methoxystilbene; CA4; CRC 87-09; NSC 817373

产品描述:

Combretastatin A4 is a natural stilbenoid phenol originally isolated from an African shrub, Combretum caffrum. It is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. CA4 was shown to impede tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma) and MCF-7 (breast cancer). It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A-4 is the active component of combretastatin A-4 phosphate, a prodrug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. Combretastatin A-4 is therefore a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis.

宿主来源:

Plant

保存温度:

-20°C

运输温度:

Ambient

预期分子量:

316.35

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at -20°C.