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折扣/货期| 货号：SIH-640-5MG | 规格：5 mg | 目录价：￥3312 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Compound E
别名:
N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
产品描述:
Gamma secretase Inhibitor
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
490.5
产品形式:
White powder
产地:
加拿大
生产商:
Stressmarq
功能与背景:
A highly potent, selective, and cell‑permeable γ‑secretase inhibitor that blocks the proteolytic processing of both amyloid precursor protein (APP) and Notch, with IC₅₀ values of ~3 nM¹˒². By inhibiting γ‑secretase–mediated cleavage of APP, the compound robustly suppresses amyloid‑β (Aβ) production, a key pathological driver in Alzheimer’s disease⁵.
In neural systems, this inhibitor demonstrates broad neuroscience‑relevant activity: it reduces proliferation and promotes differentiation of neuroblastoma cells³, and it induces neuronal differentiation from stem cells⁴, making it a valuable tool for studying neurodevelopment, neural lineage specification, and disease‑associated signaling pathways.
纯度:
≥98% (TLC); NMR (Conforms)
来源:
Synthetic
CAS号:
209986-17-4
分子式:
C27H24F2N4O3
溶解度:
May be dissolved in DMSO (25 mg/ml)
促销活动
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