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折扣/货期| 货号：SIH-639-25MG | 规格：25 mg | 目录价：￥4752 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
P7C3-A20
别名:
3,6-Dibromo--fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine
产品描述:
Neuroprotective Agent
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
506.2
产品形式:
Off-white powder
产地:
加拿大
生产商:
Stressmarq
功能与背景:
P7C3‑A20 is a neuroprotective and pro‑neurogenic small molecule that acts through stimulation of NAMPT, a key enzyme in neuronal NAD⁺ biosynthesis¹. This compound enhances neuronal survival and promotes endogenous repair mechanisms following traumatic brain injury (TBI)². In mouse models of chronic TBI, P7C3‑A20 also repairs blood–brain barrier integrity, halts progressive neurodegeneration by reversing tau phorphorylation³, and restores cognitive function⁴. Beyond TBI, it demonstrates robust neuroprotective activity in models of hypoxic–ischemic encephalopathy⁵. Additionally, P7C3‑A20 suppresses neuroinflammation and protects retinal ganglion cells from degeneration in a rat optic nerve crush model(6), highlighting its potential across multiple forms of CNS injury.
纯度:
≥98% (HPLC); NMR (Conforms)
来源:
Synthetic
CAS号:
1235481-90-9
分子式:
C22H19Br2FN2O
溶解度:
May be dissolved in DMSO (40 mg/ml)
促销活动
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