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折扣/货期| 货号：BVT-0237-C025 | 规格：25 ug | 目录价：￥840 |
| 货号：BVT-0237-C100 | 规格：100 ug | 目录价：￥1260 |
| 货号：BVT-0237-M001 | 规格：1 mg | 目录价：￥3240 |
| 货号：BVT-0237-M005 | 规格：5 mg | 目录价：￥13440 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Concanamycin A (high purity)
别名:
Folimycin; Antibiotic TAN 1323B; Antibiotic X4357B
产品描述:
Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1 (Prod. No. BVT-0252). Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Cytotoxic in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production. Concanamycin A enables the immune system to kill HIV-infected cells. Nef is an HIV-encoded accessory protein that enhances pathogenicity by down-regulating major histocompatibility class I (MHC-I) expression to evade killing by cytotoxic T lymphocytes (CTLs). Concanamycin A has been identified as potent inhibitor of Nef that restores MHC-I and enhances the clearance of HIV-infected primary cells by cytotoxic T lymphocytes. Concanamycin A counteracts Nef from diverse clades of HIV targeting multiple allotypes of MHC-I, indicating the potential for broad therapeutic utility.
宿主来源:
Isolated from Streptomyces sp.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
866.1
产品形式:
solid
有效期:
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
80890-47-7
分子式:
C46H75NO14
溶解度:
Soluble in methanol, DMSO or acetonitrile; insoluble in water.
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