Concanamycin A (high purity)-其他小分子化合物-深圳欣博盛生物科技有限公司

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Concanamycin A (high purity)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：BVT-0237-C025	规格：25 ug	目录价：￥900
货号：BVT-0237-C100	规格：100 ug	目录价：￥1260
货号：BVT-0237-M001	规格：1 mg	目录价：￥3240
货号：BVT-0237-M005	规格：5 mg	目录价：￥15600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Concanamycin A (high purity)

别名:

Folimycin; Antibiotic TAN 1323B; Antibiotic X4357B

产品描述:

Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1 (Prod. No. BVT-0252). Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Cytotoxic in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production. Concanamycin A enables the immune system to kill HIV-infected cells. Nef is an HIV-encoded accessory protein that enhances pathogenicity by down-regulating major histocompatibility class I (MHC-I) expression to evade killing by cytotoxic T lymphocytes (CTLs). Concanamycin A has been identified as potent inhibitor of Nef that restores MHC-I and enhances the clearance of HIV-infected primary cells by cytotoxic T lymphocytes. Concanamycin A counteracts Nef from diverse clades of HIV targeting multiple allotypes of MHC-I, indicating the potential for broad therapeutic utility.

宿主来源:

Isolated from Streptomyces sp.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

866.1

产品形式:

solid

产地:

瑞士