CRT0066101 . HCl-其他小分子化合物-深圳欣博盛生物科技有限公司

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CRT0066101 . HCl

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3550-M001

规格：1 mg

目录价：￥540

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

CRT0066101 . HCl

别名:

2-[4-[[(2R)-2-Aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-phenol . hydrochloride

产品描述:

CRT0066101 is an inhibitor of all three PKD isoforms (IC50s = 1, 2.5, and 2 nM for PKD1, PKD2 and PKD3, respectively). It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCalpha, PKBalpha, MEK, ERK, c-Raf, c-Src and c-Abl. PKD family members play an important role in regulating several cellular processes and activities, including chromatin organization, Golgi function, gene expression, cell survival, adhesion, motility, differentiation, DNA synthesis and proliferation. CRT0066101 shows anticancer activity by blocking cell proliferation, inducing apoptosis, G2/M phase arrest, inhibiting migration and invasion and reducing the viability of several cancer cells both in vitro and in vivo. CRT0066101 reduced PKD-dependent NF-kappaB activation and NF-kappaB-dependent gene expressions in pancreatic cancer cells in vitro and showed antiviral activities inhibiting viral RNA replication and viral protein expression. Protein kinase D (PKD) has emerged as an important NLRP3 kinase that catalyzes the release of a phosphorylated NLRP3 species that is competent for inflammasome complex assembly. PKD inhibitor CRT0066101 could block NLRP3 inflammasome assembly and interleukin-1beta production. CRT0066101 also inhibits MyD88 and TLR4 expression and reduces NF-kappaB, ERK and JNK phosphorylation, indicating that it exerts anti-inflammatory effects on LPS-induced inflammation through the TLR4/MyD88 signaling pathway.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

338.4 . 109.4

产品形式:

solid

产地:

瑞士

纯度:

>98%