| 货号:GTX80397 | 规格:100μl | 目录价:¥5600 |
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
产品名称:
CTCF antibody [1D11]
别名:
CCCTC-binding factor , MRD21
反应种属:
Human, Monkey, Mouse
宿主来源:
Mouse
实验应用:
ELISA, WB
同种型:
IgG1
免疫原:
Purified recombinant fragment of human CTCF expressed in E. Coli.
克隆性:
Monoclonal
克隆号:
1D11
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Ascites, 0.03% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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