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折扣/货期| 货号：GTX23085 | 规格：500μl | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Cyclin D2 antibody [DCS-3.1]
别名:
cyclin D2 , KIAK0002 , MPPH3
反应种属:
Human, Mouse, Rat
宿主来源:
Mouse
实验应用:
FCM, ICC/IF, IP, Neutralizing /Inhibition, WB
同种型:
IgG2a
免疫原:
Purified human recombinant full-length cyclin D2 protein
克隆性:
Monoclonal
克隆号:
DCS-3.1
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
buffer, 0.05% Sodium azide.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
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