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折扣/货期| 货号：GTX22922 | 规格：100μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RASA1 antibody [B4F8]
别名:
RAS p21 protein activator 1 , CM-AVM , CMAVM , CMAVM1 , GAP , PKWS , RASA , RASGAP , p120 , p120GAP , p120RASGAP
反应种属:
Bovine, Human, Mouse, Primate, Rat
宿主来源:
Mouse
实验应用:
ICC/IF, IP, WB
靶标/特异性:
Epitope mapping studies suggest that this antibody binds a portion of GAP that contains the src homology regions SH2 and SH3.
同种型:
IgG2a
免疫原:
Full length recombinant human GAP.
克隆性:
Monoclonal
克隆号:
B4F8
纯化方式:
Protein A purified
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
buffer, 0.05% Sodium azide.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]
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