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折扣/货期| 货号：SYN-1095-M001 | 规格：1 mg | 目录价：￥1582 |
| 货号：SYN-1095-M005 | 规格：5 mg | 目录价：￥2576 |
| 货号：SYN-1095-M010 | 规格：10 mg | 目录价：￥4690 |
| 货号：SYN-1095-M050 | 规格：50 mg | 目录价：￥14364 |
| 货号：SYN-1095-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Danusertib
别名:
PHA-739358
产品描述:
Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid tumors. Danusertib (PHA-739358) is a small molecule pan- Aurora kinase inhibitor that also has activity against other cancer-relevant kinases such as Bcr-Abl tyrosine kinase. Other off target effects of danusertib include inhibition of receptor tyrosine kinases such as FGFR-1, and TrkA. Danusertib demonstrates nanomolar IC(50) values for the Aurora kinases all under 100nM and it also demonstrates potent anti-proliferation effects in cell proliferation assays with IC(50) values ranging from 20nM for A2780 cells to <200nM.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
474.6
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
827318-97-8
分子式:
C26H30N6O3
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