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折扣/货期| 货号：CDX-A0563-M005 | 规格：5 mg | 目录价：￥546 |
| 货号：CDX-A0563-M010 | 规格：10 mg | 目录价：￥980 |
| 货号：CDX-A0563-M050 | 规格：50 mg | 目录价：￥3920 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Decitabine
别名:
5-Aza-2'-deoxycytidine; DAC; 2'-Deoxy-5-azacytidine; 4-Amino-1-(2-deoxy-beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; NSC 127716
产品描述:
Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. This cytosine analog incorporates into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects. Decitabine is a potent antileukaemic agent with activity in the treatment of haematological malignancies such as acute myeloid leukaemia (AML), chronic myeloid leukaemia (CML) and myelodysplastic syndrome (preleukaemia) and has been suggested to reverse chemotherapy resistance in several cancer types. It is used as a chemotherapeutic agent, suppresses growth of human tumor cell lines, shown to reverse embryonic stem cell differentiation and prevent atherosclerosis lesion formation and reduces the production of inflammatory cytokines by macrophages.
宿主来源:
Synthetic
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
228.21
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at RT.
产地:
瑞士
纯度:
>99% (HPLC)
CAS号:
2353-33-5
分子式:
C8H12N4O4
溶解度:
Soluble in DMSO (30mg/ml), DMF (20mg/ml) or water (1mg/ml).
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