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折扣/货期| 货号：96-235 | 规格：0.2 mg | 目录价：￥7160.4 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
DIABLO Recombinant Protein
别名:
DIABLO, SMAC
实验应用:
WB
表达系统:
E. coli
保存温度:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
20 mM Hepes, 150 mM Nacl, pH7.5
产地:
美国
生产商:
Prosci
功能与背景:
Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
纯度:
>95% as determined by SDS-PAGE.
Accession #:
NP_063940
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