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折扣/货期| 货号：CDX-D0536-G025 | 规格：25 g | 目录价：￥1246 |
| 货号：CDX-D0536-G100 | 规格：100 g | 目录价：￥2660 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Diosgenin
别名:
Nitogenin; (25R)-5-Spirosten-3beta-ol; 3beta-Hydroxy-5-spirostene
产品描述:
Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products. Diosgenin has shown many pharmacological activities. It exhibits anticancer, hypocholesterolemic, anti-diabetic, neuroprotective, immunomodulatory, anti-inflammatory, estrogenic, and skin protective effects. This is mainly by inducing apoptosis, suppressing malignant transformation, decreasing oxidative stress, preventing inflammatory events, promoting cellular differentiation/proliferation, and regulating T-cell immune response. It interferes with cell death pathways and their regulators to induce apoptosis. Diosgenin antagonizes tumor metastasis by modulating epithelial-mesenchymal transition and actin cytoskeleton to change cellular motility, suppressing degradation of matrix barrier, and inhibiting angiogenesis. Diosgenin has also been reported to reverse multi-drug resistance in cancer cells and sensitize cancer cells to standard chemotherapy. Additionally, diosgenin improves antioxidant status and inhibits lipid peroxidation. Its anti-inflammatory activity is through inhibiting production of pro-inflammatory cytokines, enzymes and adhesion molecules. Furthermore, diosgenin drives cellular growth/differentiation through the estrogen receptor (ER) cascade and transcriptional factor PPARgamma. Diosgenin has also be used to synthesize steroidal drugs. Several novel diosgenin analogs and nano-formulations have been synthesized with improved anti-cancer efficacy and pharmacokinetic profile.
宿主来源:
Plant
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
414.62
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
512-04-9
分子式:
C27H42O3
溶解度:
Soluble in ethanol (10mg/ml) or methanol. Insoluble in water or DMSO (both <1 mg/ml).
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